DECA 250

Nandrolone Phenylpropionate Injection BP 100 mg/ml

COMPOSITION:

Each ml contains:

Nandrolone Phenylpropionate BP q.s.

Ethyl Oleate BP 100mg BP q.s

PHARMACOLOGICAL CLASSIFICATIONS:

Anabolic Steroids

PHARMACOLOGICAL ACTION:

DECA 100 is an injectable anabolic preparatn. After injection Nandrolone

INDICATIONS:

As an anabolic steroid Certain cases of disseminated breast cancer in women. Osteoporosis due to androgen deficiency in hypogonadal males

CONTRA-INDICATIONS:

Not intended for use in children. Known or suspected prostatic carcinoma and mammary carcinoma in the male Not intended for use in female patients other than Ihose with disseminated breast cancer

Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure

hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma

DOSAGE AND DIRECTIONS FOR USE :

DECA 100 should be administered by deep intramuscular injection. Adult dose:The dosage is around 50-100 mg per injection, or a total of 150-300 mg/week

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:

Virilisation which appears in sensitive women as hoarseness, ache, hirsutism, and increased libido; in prepubertal boys as an increased frequency of erections and phallic enlargement, and in gids as an Increase of pubic hair and clitoral hypertrophy,Hoarseness may be the first syn'4)tom of vocal change which may end in a long-lasting, sometimes irreversible deepening of the voice.

Other adverse reactions may include:

-Oligospermia and decreased ejaculatory volume

- Suppression of ovarian activity, atrophy of the breasts and endometrial Tissue

-Amenorrhoea and inhibition of spermatogenesis

- Water and salt retention.

-Premature epiphyseal closure

-If signs of virilisation develop, treatment should be discontinued. Increase in nitrogen retention and skeletal weight

-Increased vascularity of the skin

- Increased growth of the bone

-Elderly males may become over-stimulated.

Patients with the following conditions should be monitored:

latent or overt cardiac failure, renal dysfunction,hypertension, epilepsy or migraine (or a history of these conditions), since anabolic steroids may induce salt and fluid retention

-diabetes, since anabolic steroids may improve the glucose tolerance and decrease the need for Insulin or other antidiabetic dugs

- Incomplete statural growth,since anabolic steroids in high dosages may accelerate epiphyseal closure

-skeletal metastases, since anabolic steroids may induce hypercalcaemia and hypercalciuria in these patients

- liver dysfunction

INTERACTIONS:

Liver-enzyme-inducing agents may reduce the effects of DECA 100 by enhancing its metabolism in the liver

KNOWN SYMPTOMS OF OVER DOSAGE AND PARTICULARS OF ITS TREATMENT:

See "Side-effects and special precautions". Treatment is symptomatic and supportive

STORAGE INSTRUCTIONS:

Store at room temperature below 25°C Keep out of reach of children

PRESENTATIONS:

10 ml glass vial duly labeled & packed in a printed carton along with a leaflet OR 10 Ampoules of 1 ml vial duly labeled & packed in a printed carton along with a leaflet.